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The Business Case for Accelerating Women’s Health Investment

An introduction to the billion-dollar market opportunity that lies in women’s health 

The WHAM Report: Charting a New Direction

The WHAM Report series examines the economic and health impact of investing in women’s health. Our latest report focuses on a critical question: what is the business case for accelerating investment in women’s health?

This past year reinforced a core truth WHAM has championed since its founding—investing in women’s health is not only essential, it is a significant market opportunity.

Women influence approximately 80% of healthcare decisions and are projected to control more than half of U.S. wealth by 2030, yet conditions that differently, disproportionately, or exclusively affect women remain significantly underfunded relative to their prevalence and economic impact.

These gaps represent one of the most significant opportunities in healthcare today—to improve diagnosis, treatment, and outcomes while unlocking substantial long-term value.

In this blog series, we’re going deeper and unpacking the critical findings from the 2026 WHAM Report to explore what the numbers really mean for patients, investors, researchers, and innovators. From the $360 billion ‘ghost market’ hiding in plain sight, to diagnostic gaps that take a decade to close, each post in this series brings a different piece of the evidence to life.

Charting a New Direction
A Note From Our Founder, Carolee Lee

You may notice the fish imagery once again on the cover of our report. The metaphor is intentional—and increasingly urgent.

Schools of fish move with precision and speed, shifting direction not because one commands the turn, but because each responds to subtle signals in the environment. When conditions change, they don’t hesitate—they move.

This year, that image reflects where we are now.

The health of women remains an ocean largely unexplored. For decades, the market has stayed close to familiar shores, following well-worn investment paths. But the conditions are changing. New science is surfacing. Data is clarifying long-ignored needs. What began as a quiet shift has become clear momentum.

As our understanding of sex-based differences accelerates, new territory is coming into focus. These are not theoretical opportunities—they are measurable investments emerging with the same clarity as newly mapped ecosystems beneath the ocean’s surface.

The signal is unmistakable. Research is advancing. Capital is mobilizing. Institutions are beginning to turn.

Those who recognize this shift—and act decisively—will help set the direction of the market, shape the next phase of healthcare innovation, and lead where others will follow.

Our intention is clear: to move with purpose toward what is emerging, to guide the investment and research community beyond familiar routes, and to accelerate discoveries that build stronger markets and better health outcomes for all.

The current is changing. It’s time to move.

With optimism,
Carolee Lee
Founder, CEO of WHAM,
TIME100 Global Health Leader

WHAM is dedicated to funding women’s health research and investment to transform women’s lives.

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WHAM was created in response to the considerable funding gap, historical exclusion, and underrepresentation of women in health research.

CONTACT US

Marianne Foss-Skiftesvik
Chief of Staff & Strategic Partnerships
marianne@whamnow.org

Address
19 East Elm St
Greenwich CT 06830

Phone

914-645-5264

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Donate to Women's Health Research


Women are 51% of the population but receive only a fraction of biomedical research funding. Sex differences are still often ignored, even in diseases that hit women hardest. Advancing sex-based research closes that gap, sparks innovation, and delivers more precise care for everyone. Support the future of health—for women, and for all.

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Donate to Autoimmune Disease Research


Four out of five Americans with autoimmune disease are women—40 million lives impacted—yet the science hasn’t kept up. In 2019, only 7 % of the NIH’s rheumatoid arthritis budget focused on women. Dedicated funding can pinpoint why women are so vulnerable and drive better diagnostics, therapies, and quality of life. Fuel research that will change lives.

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Donate to Brain Health Research


Women make up two-thirds of Alzheimer’s cases and are twice as likely to suffer depression—yet we still don’t know why. Targeted, sex-specific studies can reveal the biological and clinical differences that unlock earlier diagnosis, smarter treatments, and healthier minds. Your gift drives that discovery.

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Donate to Cancer Research


Most cancer studies still default to male models, overlooking critical sex differences in how cancers start, spread, and respond to therapy. Lung cancer now kills more women than breast, ovarian, and cervical cancers combined, and rates are soaring among young, non-smoking women. Boosting sex-based cancer research will reveal why—and lead to breakthroughs in screening, care, and survival. Help us accelerate that work.

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Donate to Heart Health Research


Heart disease is the No. 1 killer of women, but it remains underfunded, under-researched, and underdiagnosed. Nearly half of women over 20 have cardiovascular disease, pregnancy heart risks are widespread, and women are 50% more likely to die after a heart attack. Focused research can rewrite those odds—changing how heart disease is detected, treated, and prevented in women. Invest in saving women’s hearts.

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